Targeting Rho GTPase Signaling Networks in Cancer
نویسندگان
چکیده
منابع مشابه
The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment
Numerous large scale genomics studies have demonstrated that cancer is a molecularly heterogeneous disease, characterized by acquired changes in the structure and DNA sequence of tumor genomes. More recently, the role of the equally complex tumor microenvironment in driving the aggressiveness of this disease is increasingly being realized. Tumor cells are surrounded by activated stroma, creatin...
متن کاملRational design of Rho GTPase-targeting inhibitors.
Rho GTPases have been implicated in diverse cellular functions and are potential therapeutic targets in inflammation, cancer, and neurologic diseases. Virtual screening of compounds that fit into surface grooves of RhoA known to be critical for guanine nucleotide exchange factor (GEF) interaction produced chemical candidates with minimized docking energy. Subsequent screening for inhibitory act...
متن کاملRho-GTPase signaling in leukocyte extravasation
Leukocyte transendothelial migration (TEM) is one of the crucial steps during inflammation. A better understanding of the key molecules that regulate leukocyte extravasation aids to the development of novel therapeutics for treatment of inflammation-based diseases, such as atherosclerosis and rheumatoid arthritis. The adhesion molecules ICAM-1 and VCAM-1 are known as central mediators of TEM. C...
متن کاملRho GTPase signaling modulates neurotransmission in Caenorhabditis elegans
Hu, Shuang, "Rho GTPase signaling modulates neurotransmission in Caenorhabditis elegans" (2013). Theses and Dissertations. Paper 100. Rho family GTPases act as molecular switches in the regulation of diverse cellular functions, including cell division, gene transcription and neurotransmission. In the model organism Caenorhabditis elegans, the Kalirin and Trio ortholog UNC-73 contains two RhoGEF...
متن کاملWnt and Rho GTPase signaling and their interaction
Th e disability burden and prevalence of osteoarthritis (OA) in both developed and developing countries is increasing due to an aging population. OA is a degenerative joint disease that is characterized by cartilage degradation and osteophyte formation. It involves multiple components of the joint, including the synovial joint lining, peri-articular bone and adjacent supporting connective tissu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.00222